MatriceLAB Innove’s activities focus on the role of the immune system in embryo implantation. At the time of embryo transplant, a unique immune reaction takes place in the endometrium. This is an essential reaction to promote adhesion of the embryo and to regulate the invasion of the endometrium by the embryo. Imbalance affecting this reaction is one of the causes of failure to implant, or early miscarriage

Learn more about implantation and the immunity dialogue

The principle

Thanks to work relying on more than 10 years of academic research, we have developed a diagnostic test which analyses several biomarkers.

Identification of immunological markers which are specific to the endometrium during the implantation window allows us to:

  • create a profile of uterine receptivity immunological balance
  • determine imbalances of this immunological profile which provide understanding of the mechanisms which cause implantation failures (a fault or, on the contrary, a locally excessive immunological activity which can cause failure of an embryo implant)
  • best adjust the efforts for future procreation in establishing immunological balance.

The immunological uterine profile for each patient is determined in order to understand the mechanisms which could contribute to implantation failure or a miscarriage. Based on this mechanism, we propose a treatment strategy to physicians which is best-suited to each patient in order to establish immunological balance, and thus favour implantation. Our results are a birth rate of 40%, following application of the proposed treatment, at the next embryo transplant after performing the MatriceLAB test.

To whom is this addressed?

  • To women presenting with repeated and unexplained implantation failures after several attempts at IVF/ICSI.
  • For women with several unexplained miscarriages
  • For couples who wish to use a donation of oocytes and would like to ensure beforehand that they are properly receptive in order to optimise attempts

MatriceLAB Innove is not currently authorised to receive or process samples which are positive for HIV, hepatitis B and C. Immunity analysis of uterine receptivity is unfortunately not available to women with HIV, hepatitis B or C.

In practice

Immune testing for uterine receptivity is done with a biopsy of the endometrium performed classically by your gynaecologist using a Cornier pipette (see FAQ section).

It is important to perform an ultrasound on the day of the biopsy in order to judge thickness and the vascularisation state of the endometrium. Immunological analysis must be completed using histological dating (in order to ensure that the biopsy is well done during the secretory phase of the cycle), and is done by a testing laboratory with which we work.

That is why the biopsy must be divided into two parts:

  • one for MatriceLAB Innove
  • one for the pathology centre

Uterine receptivity testing is done outside of all IVF cycles, classically, 5 to 9 days after ovulation (determine the date with your gynaecologist). The biopsy can be performed during a natural cycle, but we recommend performing it with a substitute cycle (oestrogen and progesterone), ideally one week before the start of taking progesterone. In fact, nearly 3% of biopsies performed during a natural cycle cannot be tested, because the biopsy was not performed during an implantation window; patients are then requested to have a new biopsy taken.

MatriceLAB Innove sends all the material needed (for immunological testing of uterine receptivity and histological dating) directly to the physician upon request. The material is sent once a week, on Wednesdays.

Several documents must be filled out and/or signed (see foot of this page).
It is essential to take the time to correctly fill in the information in order to prevent any delay in processing tests and to have a custom result.

Samples and documents must be sent to MatriceLAB Innove and to the pathology centre by post in provided envelopes or using a specialised courier for patients with cured hepatitis B. We recommend sending it quickly so that the biopsy arrives in less than 48 hours. We recommend not sending at the end of the week or before the weekend, and to keep the sample (in its package) in the refrigerator in the meantime.

In fewer than 2 weeks after receiving the biopsy, you will receive an invoice by email which states the amount to pay for the tests (see FAQ section). Your results will be sent to you by post within 3-4 weeks from the time we have received the biopsy. Your physician will also receive more detailed notes with recommendations for treatment to put in place for your next IVF/ICSI attempt. We ask you to contact him for all questions relating to interpretation of your tests and the proposed therapeutic strategy.

After the biopsy

We advise waiting two cycles between taking your biopsy and your next IVF/ICSI attempt. In effect, it takes four weeks to obtain biopsy results and, in certain treatment cases, the proposed treatment starts at the end of the cycle before the IVF/ICSI attempt. We recommend, however, starting your next IVF/ICSI attempt within six months following taking of the biopsy. The uterine environment can evolve with your cycles, and we don’t have information beyond nine months to know if the proposed treatment is suitable for your case.

If a local immune imbalance is detected, we advise that your undertake a new test under therapy. The goal of this is to ensure that the proposed treatment functions well, and can be adjusted if needed (see R&D section).

Reason for uterine receptivity immunity test

Below is a table of birth rates following application of therapeutic recommendations proposed by MatriceLAB Innove. The results were obtained from a cohort of 394 women with embryo implantation failures (no implantation despite a transfer of eight embryos, on average).

We found dysregulation of the immune environment in 81.5% of cases. We present here only the cases of dysregulation for which the proposed treatment was properly applied. The second table compares the results of patients with immune over-reaction who had conducted an attempt directly after their result as compared to those with immune over-reaction who, before another attempt, verified the efficacy of treatment (in having a biopsy with the proposed treatment). For the latter group, the treatment could be modified based on the results of their second biopsy (see R&D section).

Dérégulation de l’environnement immunitaire décelée

 Immune under-activationImmune over-activation
Birth rate47,5%37,2%

Patients with immune over-activation

 
Without verification of the efficacy of the treatment

After verification of the efficacy of the treatment (new biopsy under treatment)
Birth rate35,8%46,6%

Physician and patient documents

Documents for physicians

Documents for patients